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The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Upload Special offers. In Stock. Prescription Required. Product Details. Directions for Use For intramuscular use only. Lupi-HCG Injection will be administered by a healthcare professional.
Storage Store in a cool and dry place away from sunlight. Drug Interactions Drug-drug interactions: No interactions found. Drug-food interactions: No interactions found. Safety Advice. Pregnancy Consult Your Doctor. Breast Feeding. Habit Forming No. Avoid processed or high-sugar foods. Stay active and shed excess weight if you are overweight or obese.
Do not perform intense exercises as they may negatively impact your reproductive health. Increase the intensity of exercise gradually. Being underweight may also affect fertility. So, prepare a diet chart that can help you to gain weight healthily.
Avoid stress as it may affect your fertility. We used Generalized Estimating Equations GEE to identify independent factors contributing to the success positive pregnancy test and clinical pregnancy rate of the IUI cycle. This model takes into account that there may more than one observation per patient. All the factors were treated as dichotomous variables, except the cycle day of insemination, which was a continuous variable. The selected cut-off points for sperm count and number of follicles were arbitrarily chosen.
The statistical analysis consisted of intrauterine inseminations. There were 99 patients who had two inseminations and who had only one insemination. The urinary pregnancy test yielded a positive result in 45 cycles, giving a pregnancy rate of The clinical pregnancy rate was In 25 out of cycles 7. Those who conceived were more likely to have unexplained infertility and less likely to have male factor as the main diagnosis.
Comparison of characteristics between those who tested positive and negative in urinary pregnancy test. The pregnancy rate was The clinical pregnancy rates were 9. The aim of the GEE analysis here was to find independent factors affecting the cycle outcome.
Male factor, unexplained infertility or the insemination cycle day were not independent factors and were, therefore, not included in the model.
Postponing the hCG administration until after the IUI instead of injecting it hours before IUI resulted in a significantly increased pregnancy rate. In most studies that have evaluated the outcome in IUI cycles, the insemination has been performed hours following hCG administration [ 1 , 4 ]. This practice is based on data indicating that, in natural cycles, the ovulation takes place 32 hours range hours after the onset of the luteinizing hormone LH surge [ 5 ], whereas in stimulated cycles, it takes place approximately hours after the hCG injection [ 6 ].
As the current assumption is that the oocytes are fertilisable for only hours [ 7 ] and the spermatozoa survive only for a limited period of time in the female reproductive tract [ 8 - 10 ], it is rational to schedule the insemination to the time of expected ovulation, i.
In , Wilcox et al. After stopping birth-control methods, the women collected daily urine specimens and kept daily records of their sexual intercourses. Oestrogen and progesterone metabolites were measured from the urine samples to estimate the day of ovulation. The authors observed that conception occurred only when intercourse took place during a six-day period that ended on the estimated day of ovulation [ 3 ]. This finding suggests that the chances to conceive in the natural cycle diminish considerably after ovulation and that, preferably, the spermatozoa should be available in the reproductive tract before ovulation occurs.
It also suggests that spermatozoa may survive for several days after intercourse, as women whose last intercourse took place days before ovulation did conceive. The results of the study by Wilcox et al. The change in hCG administration ensured that the spermatozoa were already present in the reproductive duct before ovulation took place, similar to the situation in successful natural cycles [ 3 ].
Since sexual intercourse was allowed a couple of days before the insemination and also after it, spontaneous conception is possible although unlikely, since all of the couples had at least one year infertility even before the start of basic investigations.
Since our study was retrospective and only limited number of outcomes were presented, the finding needs to be confirmed in randomised controlled trials. IYJ has participated in designing the study, acquisition, analysis and interpretation of data, drafting and revising the article. JST has participated in interpretation of data and revising the article. HM has participated in acquisition and interpretation of data and revising the article.
All the authors read and approved the final manuscript. National Center for Biotechnology Information , U. Journal List Reprod Biol Endocrinol v. Reprod Biol Endocrinol. Published online Feb Author information Article notes Copyright and License information Disclaimer. Corresponding author.
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